In lieu of an abstract, here is a brief excerpt of the content:Making the Best of Things: Character Skepticism and Cross-Cultural PhilosophyJohn M. Doris (bio)With your spirit settled, accumulate practice day by day, and hour by hour.—Miyamoto MusashiLike many of my colleagues in moral psychology, I’ve focused almost exclusively on Western philosophy, so I was pleasantly surprised when practitioners of cross-cultural and comparative philosophy responded to character skepticism with resources drawn from Eastern traditions.1 [End Page 571]As a reminder: the (...) character skeptic asserts a descriptive claim, to the effect that traditional conceptions of character are empirically inadequate, accompanied by a prescriptive claim to the effect that, as a result of this inadequacy, traditional notions of character should receive considerably diminished emphasis in ethical thought (e.g., Doris 2022, p. 2).2 The antiskeptic rejects both claims: a suitably nuanced conception of character has nothing to fear from empirical moral psychology and may safely retain its focal role in ethical thought.Near as I can see, cross-cultural philosophers commenting on the issues have generally been anti-skeptical. This anti-skepticism might be either contrastive or complementary in tenor. In a contrastive approach, Eastern conceptions of character, while bearing some affinities to Western conceptions (if there are no affinities, we’d have a change of subject), are supposed to be substantially different than Western notions, so defending the West by way of the East marks a departure from the Western characterological tradition. In a complementary approach, the Eastern and Western conceptions are substantially similar, so defending the West by way of the East is fundamentally a continuation of the Western characterological tradition. (Though continuation can’t be quite the right word, since the referenced Eastern traditions are often older than the Western.)While this dichotomy, like most dichotomies, oversimplifies, my sense is that cross-cultural philosophy’s contributions have tended to be complementary: consideration of Eastern traditions, often times Confucian, is said to illuminate what’s valuable in Western, frequently Aristotelian, traditions.3 This circumstance is both surprising to, and convenient for, me. Surprising, for my reading of the one Eastern text I have studied closely,4 over my thirty-five-year avocation as a martial artist, the legendary swordsman Miyamoto Musashi’s Book of Five Rings (Musashi/Harris 1974), suggests a contrastive reading: courage seems nearly invisible in Musashi’s treatment of success in combat, while martial valor is central to Aristotle’s understanding of courage. In any case, that those with vastly more scholarly credibility than I have favored complementary projects is a welcome convenience for me, since it allows me to enter discussion of cross-cultural philosophy and character along my usual pathways in contemporary Western moral psychology.Paul Condon, Seth Robertson, and Matthew Spencer, the gracious and insightful commentators for this symposium on my essay collection, Character Trouble (2022), seem generally to favor a complementary approach: while careful to note the existence of differences, they find in Eastern traditions resources to blunt the force of character skepticism as applied to its usual target, virtue ethics in a broadly Aristotelian tradition.5 Quite expectedly, in my responses, I’ll beg to differ. The essays in question span over twenty years, and on the main points of character skepticism, I’ve failed to change my mind in the face of (sometimes strident) criticism, so it’s [End Page 572] unlikely I would do so now, despite my commentators’ astute recommendations. In fact, I’m now more convinced of character skepticism than when I started, or at least have better arguments for it (more on this below). Nevertheless, my commentators have done much to enrich the issues; in this unavoidably and regrettably incomplete response, I’ll attempt to enrich things a bit more.Framing the Rhetorical SpaceI take it my commentators and I are united in thinking that the kind of empirical moral psychology embodied in character skepticism and celebrated in Character Trouble (CT) has important implications for how philosophers and psychologists should think about character and virtue.6 This makes refreshing contrast with early responses to character skepticism from the 2000s, which often insisted that things could go on pretty much as they had before interdisciplinary moral psychologists set to work... (shrink)

Graphical AbstractAdenosine Deaminases Acting on RNA (ADARs) enzymes are prominent regulators of neural transcriptome diversity and play a role in the innate immune response. In article number 1800239, Piontkivska et al. outline how neurodevelopmental and neurodegenerative pathogenesis of Zika virus (ZIKV), including congenital Zika and Guillain-Barré syndromes, can be attributed to ADAR editing dysregulation triggered by ZIKV, Explaining Pathogenicity of Congenital Zika and Guillain-Barré Syndromes: Does Dysregulation of RNA Editing Play a Role? DOI: 10.1002/bies.201800239.

Previous studies of Zika virus (ZIKV) pathogenesis have focused primarily on virus‐driven pathology and neurotoxicity, as well as host‐related changes in cell proliferation, autophagy, immunity, and uterine function. It is now hypothesized that ZIKV pathogenesis arises instead as an (unintended) consequence of host innate immunity, specifically, as the side effect of an otherwise well‐functioning machine. The hypothesis presented here suggests a new way of thinking about the role of host immune mechanisms in disease pathogenesis, focusing on dysregulation of post‐transcriptional RNA (...) editing as a candidate driver of a broad range of observed neurodevelopmental defects and neurodegenerative clinical symptoms in both infants and adults linked with ZIKV infections. The authors collect and synthesize existing evidence of ZIKV‐mediated changes in the expression of adenosine deaminases acting on RNA (ADARs), known links between abnormal RNA editing and pathogenesis, as well as ideas for future research directions, including potential treatment strategies. (shrink)

While nothing justifies atrocity, many perpetrators manifest cognitive impairments that profoundly degrade their capacity for moral judgment, and such impairments, we shall argue, preclude the attribution of moral responsibility.

The purpose of this book is to give a coherent account of the different perspectives on science and technology that are normally studied under various disciplinary heads such as philosophy of science, sociology of science and science policy. It is intended for students embarking on courses in these subjects and assumes no special knowledge of any science. It is written in a direct and simple style, and technical language is introduced very sparingly. As various perspectives are sketched out in this (...) book, the reader moves towards a consistent conception of contemporary science as a rapidly changing social institution that has already grown out of its traditional forms and plays a central role in society at large. It will appeal to students in a wide range of scientific disciplines and complement well Professor Ziman's earlier books. (shrink)

This study makes a substantial contribution to our understanding of the development of ancient Platonism and of the influence of Greek philosophy on Christian thought. The author examines a number of themes such as Eros, Virtue, and Knowledge in the writings of Plato.

Arguments in natural theology have recently increased in their number and level of sophistication. However, there has not been much analysis of the ways in which these arguments should be evaluated as good, taken collectively or individually. After providing an overview of some proposed goals and good-making criteria for arguments in natural theology, we provide an analysis that stands as a corrective to some of the ill-formed standards that are currently in circulation. Specifically, our analysis focuses on the relation between (...) the veracity of the premises and their relation to the conclusion of an argument. In addition to providing a clearer account of what makes an argument good, an upshot of our account is that there remain positive contributions for "weak" arguments, especially within cumulative case arguments in ramified natural theology. (shrink)

Signal transduction pathways constructed around a core module of three consecutive protein kinases, the most distal being a member of the extracellular signal‐regulated kinase (ERK) family, are ubiquitous among eukaryotes. Recent work has defined two cascades activated preferentially by the inflammatory cytokines TNF‐α and IL‐1‐β, as well as by a wide variety of cellular stresses such as UV and ionizing radiation, hyperosmolarity, heat stress, oxidative stress, etc. One pathway converges on the ERK subfamily known as the ‘stress activated’ protein kinases (...) (SAPKs, also termed Jun N‐terminal kinases, JNKs), whereas the second pathway recruits the p38 kinases. Upstream inputs are diverse, and include small GTPases (primarily Rac and Cdc42; secondarily Ras) acting through mammalian homologs of the yeast Ste20 kinase, other kinase subfamilies (e.g. GC kinase) and ceramide, a putative second messenger for certain TNF‐α actions. These two cascades signal cell cycle delay, cellular repair or apoptosis in most cells, as well as activation of immune and reticuloendothelial cells. (shrink)

It is shown that in a range of models, the probability that a forager dies from starvation is, to a good approximation, an exponential function of energy reserves. Using a time and energy budget for a 19g passerine, we explore the consequences, in terms of starvation and predation, of various levels of energy reserves. It is shown that there exists an optimal level L of reserves at which total mortality (starvation plus predation) is minimized. L increases when the environment deteriorates (...) as a result of a decrease in either temperature or mean gross gain or an increase in the mean search time. The effect of combined deteriorations is greater than the sum of their individual effects. At L, the probability of predation is much higher than the probability of starvation. A simple analytic model suggests that this result will be fairly general, but also indicates conditions under which the result might not hold. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:275 DAVID HUME AND THE CONCEPT OF VOLITION Introduction The following two papers, though separately authored, belong together, not only because we, the authors, shared our views during the writing, but also because they are excerpts from a single story we are interested in telling. This is the story of a particular insight into the conceptual structure of human volition — the will. The insight is that volition — (...) or, more precisely, intention — is (or presupposes) a kind of knowledge, practical knowledge. Our larger goal is to show how this insight was developed from the time of Aristotle into the Middle Ages, and then fell into obscurity in modern philosophy until quite recently. This insight became especially clear in the writings of Thomas Aquinas. The epistemological development which obscured it was most powerfully furthered by David Hume. The recovery of the insight was initially the work of the later Wittgenstein. The first paper deals with Aquinas; the second with Wittgenstein; and both with Hume.... (shrink)

Some philosophers have claimed that emotions are states of mind where an object is taken seriously. Seriousness, as this paper understands it, involves both a phenomenological change in attention and non-indifference towards an object. The paper investigates how contemporary theories of emotion can explain the seriousness of emotion. After rejecting explanations based on feeling, desire, and concern, the paper argues that the seriousness of an emotion can be explained as the manifestation of a concern in an outwardly directed feeling. Given (...) the lack of competing explanations, seriousness probably must be explained this way. This argument shows how emotional feelings constitutively depend on desires, and why desires are essential ingredients to emotion. (shrink)

In numerous works, Alvin Plantinga argues that classical foundationalism is a failed theory of knowledge because of its self-referential incoherence. Plantinga's argument, however, fails to demonstrate that classical foundationalism is self-refuting. To bring this to light, I will review the form of Plantinga's argument in comparison with other examples of self-refutation. Upon closer inspection, it will be clear that classical foundationalism is not self-refuting, as Plantinga claims. Furthermore, I will expose another flaw in Plantinga's argument against classical foundationalism, which shows (...) at best that Plantinga's argument cannot be reconstructed to demonstrate that classical foundationalism is improbable. While Plantinga's argument may highlight a challenge for classical foundationalism, his argument does not establish the falsity ofclassical foundationalism, nor does it offer any other overriding reason to reject it. Thus, Plantinga's criticisms of classical foundationalism by themselves are not sufficient to rule out the theory's viability. South African Journal of Philosophy Vol. 26 (3) 2007: pp. 245-251. (shrink)

Martha Nussbaum proposes a universal list of human capabilities as the basis for fundamental political principles. She claims that the list, in an Aristotelian spirit, might be justified by an ongoing inquiry into valuable human functionings for the good life. Here I argue that the attractiveness of Nussbaum’s theory crucially depends on the philosophical possibility of a non-reductionist understanding of naturalism and on resolving the tensions between ethical and political aspects of the role of capabilities. Through a comparison of Nussbaum’s (...) approach with those of Aristotle and (less familiarly) Hume, I try to show that in these alternative versions we find valuable resources for the kind of non-reductionist model which might, in line with Nussbaum’s own objectives, provide the basis for a capabilities-based critique of dominant modes of normative theorizing and their influence in public discourse. (shrink)

Timothy Williamson has offered a novel approach to refuting external world skepticism in his influential book, Knowledge and Its Limits. The strategy employed by Williamson is to show that skeptics falsely attribute too much self-knowledge to the epistemic agent when they claim that one’s evidence is the same when in a “good case” as it would be in a similar “bad case.” Williamson argues that one’s evidence is not the same in a good case as it would be in a (...) bad case. My contention is that Williamson’s account fails. In order to make his case against skepticism, Williamson must attribute an overly strong conception of evidence to the skeptic, which can be avoided by appealing to a phenomenal concept of evidence. Thus, a different approach must be taken to avoid skeptical consequences. (shrink)

If now we turn to the recent translation of the Politics by Carnes Lord we see that the language of "rights" is completely avoided. Lord prefers to speak sometimes in terms of what a person or group of persons is "entitled to" under the laws, or of what is "open" or "permitted" to them; and he usually or always sticks to "justice" or a related term to translate δίκαιον and its derivatives--whether this is justice as established by the laws of (...) a given community or type of community, or the true or correct account of what justice is and demands. It is doubtful, though, whether Lord avoids rights-talk as a matter of interpretative principle. He aims to translate key terms of the Greek with a single English translation throughout, with the result that, since in any event Aristotle uses no single Greek term where we might be tempted to speak of rights, avoiding the language of rights may have seemed to him required simply by his conception of "literal" translation. In his glossary under the heading "Justice," he explicates τὸ δίκαιον in part as "a right or rightful claim" and adds that this sense is generally rendered in his translation by "[claim to] justice." So, if we take this glossary entry as giving his full view, Lord would not object to at least interpreting Aristotle in these passages as speaking of rights or rightful claims. However, Lord is a follower of Leo Strauss and in his avoidance of the noun "right" to render anything Aristotle says, he may also have been falling in with Strauss's own considered view, which was that any attribution of a notion of "rights" to Aristotle or any other ancient thinker is so grossly anachronistic that it must be strictly avoided. In the past forty years or so I think it is fair to say that this view of Strauss's has been shared increasingly by important writers on ancient politics and political thought. Perhaps this tendency is all the more prevalent with the onset of self-described "post-modernist" thought and the historicism in all interpretation of the past that it so often connotes. Is there anything to this objection of vicious anachronism? Were Barker and other older writers making a serious error in rendering and interpreting Aristotle so as to make him hold theories about various ancient constitutions as granting political and other legal rights to people living under them, and also theories of his own about the rights people have under justice as to what their political and legal rights shall be? A major thesis of Fred Miller's recent book, Nature, Justice, and Rights in Aristotle's Politics is that they were not--at least they were not, once certain distinctions are carefully drawn, and one is careful to state what is and what is not implied by the "rights" talk they were so readily finding in Aristotle's texts. In what follows I will limit myself to discussing this thesis of Miller's and his handling of it. (shrink)

Ramsey's “Facts and Propositions” is terse, allusive, and dense. The paper is far from easy to understand. The present essay is an effort, largely following Brian Loar's account,1 to say what Ramsey's goal is, to spell out what he took to be the means to accomplish it, and to show how those means, at least in the terms of F&P, cannot accomplish that end. I also contrast Loar's own account of judgment, explicitly modeled on Ramsey's view, with the latter. The (...) exercise is not at all academic. Loar makes clear the striking depth and originality of Ramsey's insights. (shrink)

How does deductive logic constrain probability? This question is difficult for subjectivistic approaches, according to which probability is just strength of (prudent) partial belief, for this presumes logical omniscience. This paper proposes that the way in which probability lies always between possibility and necessity can be made precise by exploiting a minor theorem of de Finetti: In any finite set of propositions the expected number of truths is the sum of the probabilities over the set. This is generalized to apply (...) to denumerable languages. It entails that the sum of probabilities can neither exceed nor be exceeded by the cardinalities of all consistent and closed (within the set) subsets. In general any numerical function on sentences is said to be logically coherent if it satisfies this condition. Logical coherence allows the relativization of necessity: A function p on a language is coherent with respect to the concept T of necessity iff there is no set of sentences on which the sum of p exceeds or is exceeded by the cardinality of every T-consistent and T-closed (within the set) subset of the set. Coherence is easily applied as well to sets on which the sum of p does not converge. Probability should also be relativized by necessity: A T-probability assigns one to every T-necessary sentence and is additive over disjunctions of pairwise T-incompatible sentences. Logical T-coherence is then equivalent to T-probability: All and only T-coherent functions are T-probabilities. (shrink)

The problem of ‘wayward causal chains’ threatens any causal analysis of the concept of intentional human action. For such chains show that the mere causation of an action by the right sort of belief and/or desire does not make the action intentional, i.e. one done in order to attain the object of desire. Now if the ‘because’ in ‘wayward’ action-explanations is straightforwardly causal, that might be argued to indicate by contrast that the different ‘because’ of reasons-explanations (which both explain and (...) justify) is non-causal. Myles Brand, in Intending and Acting (1984), resists this conclusion, but argues that waywardness shows that philosophers must ‘naturalize’ action theory by drawing on contemporary work in cognitive science and artificial intelligence. I argue that this is a misconceived response to the problem of waywardness: in Brand’s work action theory itself has gone astray, unsure which way to tum next. (shrink)

Proper names often have shorter variants, e.g., the Boston Common the Common, New York City New York. A description of this phenomenon is proposed that decomposes it into four sub‐processes: Category Ellipsis, Location Ellipsis, Appellation Formation, and Explicit Metonomy. Discussion focusses principally on the former two processes, which produce “nameheods”—briefer alternations of proper names that preserve the naming function. It is argued that the name shortening processes (a) operate in a lexical domain; but (b) are non‐grammatical. An extra‐grammatical analysis of (...) the processes is outlined. (shrink)